How long will doxycycline stay in my system and cause side effects?

I’ve been taking doxycycline for 4 weeks now. Last week, I developed a terrible burning, hot, raw feeling in my palms. My doctor said it was “unlikely but not impossible” that the doxy was causing it, so I stopped taking it about 4 days ago. However, the burning is continuing. I’m wondering how long the drug will stay in my system. I asked my pharmacist and he seemed to have no clue. Kept saying “um” and “I don’t know,” and told me “maybe 2 days.” Help? Is he right?

I’ve found a number of people online who’ve had burning hands while taking doxy, so I feel like it can’t be a coincidence, but I’m wondering why it won’t go away…

3 Answers

  • Doxycycline is an antibiotic generally taken twice a day. It is taken this way because it starts to lose its affect after about 10-12 hours. by taking it twice, it maintains the level required to fight the infection it is being prescribed for (unless taken as prophylaxis for Acne).

    With that said, all of the drug should be out of your body within 3-5 days I would think. But that depends on your metabolism and other health problems that could prevent the drug from being eliminated from your system.

    Best bet – check with your local pharmacists. They are drug experts where physicians, although knowledgeable, are not necessarily experts when it come to pharmacology.

  • Doxycycline should pass through your system withing 48 to 72 hours. Rashes are considered to be an allergic reaction. You can contact the drug manufacturer or the FDA to see if this has been a reported side effect and reccomendations for dealing with it.


    ANTIBIOTICS KILL BACTERIA! Screwing up dosage causes FAILURE of treatment….DUH? Prefer to good ahead & rot??? Brilliant move.

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